Volker J Schmid
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Spatial Distribution and Birth Prevalence of Congenital Heart Disease in Iran: A Systematic Review and Hierarchical Bayesian Meta-Analysis
Background This study aimed to comprehensively analyze the overall congenital heart disease (CHD) prevalence in live births and …
Roghaye Farhadi
,
Hassankiadeh
,
Annette Dobson AM
,
Somayeh Rahimi
,
Abdollah Jalilian
,
Volker J Schmid
,
Behzad Mahaki
Maximum Entropy Technique and Regularization Functional for Determining the Pharmacokinetic Parameters in DCE-MRI
This paper aims to solve the arterial input function (AIF) determination in dynamic contrast-enhanced MRI (DCE-MRI), an important …
Zahra Amini Farsani
,
Volker J. Schmid
DOI
Modified Maximum Entropy Method and Estimating the AIF via DCE-MRI Data Analysis
Background: For the kinetic models used in contrast-based medical imaging, the assignment of the arterial input function named AIF is …
Zarah Amini Farsani
,
Volker J. Schmid
Project
DOI
Distinctive nuclear zone for RAD51-mediated homologous recombinational DNA repair.
Genome-based functions are inseparable from the dynamic higher-order architecture of the cell nucleus. In this context, the repair of …
Yasunori Horikoshi
,
Hiroki Shima
,
Jiying Sun
,
Wataru Kobayashi
,
Volker J. Schmid
,
Hiroshi Ochiai
,
Lin Shi
,
Atsuhiko Fukuto
,
Yasuha Kinugasa
,
Hitoshi Kurumizaka
,
Tsuyoshi Ikura
,
Yolanda Markaki
,
Shin-ichi Tate
,
Kazuhiko Igarashi
,
Thomas Cremer
,
Satoshi Tashiro
Project
DOI
Zusammenhang zwischen der regionalen Siedlungsstruktur und der Krankenhausinzidenz, Therapieform und Mortalität von nicht-rupturierten abdominalen Aortenaneurysmen. Sekundärdatenanalyse der deutschen DRG-Statistik von 2005–2014
Alexander Erk
,
Matthias Trenner
,
Michael Salvermoser
,
Benedikt Reutersberg
,
Volker J. Schmid
,
Hans-Henning Eckstein
,
Andreas Kuehnl
DOI
Co-localization analysis in fluorescence microscopy via maximum entropy copula
Co-localization analysis is a popular method for quantitative analysis in fluorescence microscopy imaging. The localization of marked …
Zahra Amini Farsani
,
Volker J. Schmid
DOI
Relationship between regional settlement structure and hospital incidence, type of therapy and mortality of non-ruptured abdominal aortic aneurysms
Introduction: In Germany, the regional settlement structure is heterogenous, ranging from densely populated cities with a tight network …
Alexander Erk
,
Matthias Trenner
,
Michael Salvermoser
,
Benedikt Reutersberg
,
Volker J. Schmid
,
Hans-Henning Eckstein
,
Andreas Kuehnl
DOI
Geographic risk of general and abdominal obesity and related determinants in Iranian children and adolescents: CASPIAN-IV Study
Background: Obesity, as a risk factor for many noncommunicable diseases, is a common public health problem in developed and developing …
Maryam Yazdi
,
Roya Kelishadi
,
Volker J. Schmid
,
Mohammad-Esmaeil Motlagh
,
Ramin Heshmat
,
Marjan Mansourian
DOI
The effects of minimum caseload requirements on management and outcome in abdominal aortic aneurysm repair
Matthias Trenner
,
Michael Salvermoser
,
Albert Busch
,
Volker J. Schmid
,
Hans-Henning Eckstein
,
Andreas Kuehnl
DOI
Cohesin depleted cells pass through mitosis and reconstitute a functional nuclear architecture.
The human genome forms thousands of “contact domains”, which are intervals of enhanced contact frequency. Some, called “loop domains” …
Marion Cremer
,
Katharina Brandstetter
,
Andreas Maiser
,
,
Suhas S P Rao
,
Volker J. Schmid
,
Namita Mitra
,
Stefania Mamberti
,
Kyle-N Klein
,
David M Gilbert
,
Heinrich Leonhardt
,
Maria Cristina Cardoso
,
Erez Lieberman Aiden
,
Hartmann Harz
,
Thomas Cremer
Project
DOI
Regional variation in endovascular treatment rate and in-hospital mortality of abdominal aortic aneurysms in Germany. Secondary data analysis of nationwide hospital DRG data from 2012 to 2014
Background: Abdominal aortic aneurysms (AAA) can be treated by either open surgery (OAR) or endovascular aortic repair (EVAR). The aim …
Matthias Trenner
,
Michael Salvermoser
,
Benedikt Reutersberg
,
Albert Busch
,
Volker J. Schmid
,
Hans-Henning Eckstein
,
Andreas Kuehnl
DOI
Spatio-temporal pattern of two common cancers among Iranian woman: An adaptive smoothing model
Mehdi Raei
,
Volker J. Schmid
,
Majid Moayyed
,
Behzad Mahaki
PDF
The impact of model assumptions in scalar-on-image regression
Complex statistical models such as scalar-on-image regression often require strong assumptions to overcome the issue of …
Clara Happ
,
Sonja Greven
,
Volker J. Schmid
Preprint
Code
DOI
Regionale Haeufigkeit von revaskularisierenden Prozeduren bei Karotisstenose in Deutschland
For Germany, regional variation of procedure rates of carotid endarterectomy (CEA) and carotid artery stenting (CAS) performed for …
Andreas Kuehnl
,
Michael Salvermoser
,
Eva Knipfer
,
Andreas Zimmermann
,
Volker J. Schmid
,
Hans-Henning Eckstein
DOI
Spatial Analysis of Hospital Incidence and in Hospital Mortality of Abdominal Aortic Aneurysms in Germany: Secondary Data Analysis of Nationwide Hospital Episode (DRG) Data
Objective: This study aimed to analyze the spatial distribution and regional variation of the hospital incidence and in hospital …
Andreas Kuehnl
,
Michael Salvermoser
,
Alexander Erk
,
Matthias Trenner
,
Volker J. Schmid
,
Hans-Henning Eckstein
DOI
Joint Spatio-Temporal Shared Component Model with an Application in Iran Cancer Data
Behzad Mahaki
,
Yadollah Mehrabi
,
Amir Kavousi
,
Volker J. Schmid
DOI
Editors Choice – High Annual Hospital Volume is Associated with Decreased in Hospital Mortality and Complication Rates Following Treatment of Abdominal Aortic Aneurysms: Secondary Data Analysis of the Nationwide German DRG Statistics from 2005 to 2013
Matthias Trenner
,
Andreas Kuehnl
,
Michael Salvermoser
,
Benedikt Reutersberg
,
Sarah Geisbuesch
,
Volker J. Schmid
,
Hans-Henning Eckstein
DOI
Bivariate spatiotemporal disease mapping of cancer of the breast and cervix uteri among Iranian women
Cervical cancer in women is one of the most common cancers and breast cancer has grown dramatically in recent years. The purpose of …
Mehdi Raei
,
Volker J. Schmid
,
Behzad Mahaki
DOI
Quantitative analyses of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy
Recent advancements of super-resolved fluorescence microscopy have revolutionized microscopic studies of cells, including the …
Volker J. Schmid
,
Marion Cremer
,
Thomas Cremer
Project
DOI
Maximum Entropy Approach in Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Zarah Amini Farsani
,
Volker J. Schmid
Project
DOI
Inzidenz, Therapie und Letalitat abdominaler Aortenaneurysmen
Andreas Kuehnl
,
Alexander Erk
,
Matthias Trenner
,
Michael Salvermoser
,
Volker J. Schmid
,
Hans-Henning Eckstein
DOI
Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters
Background: The association of active transcription regulatory elements (TREs) with DNAse I hypersensitivity (DHS[+]) and an open local …
Marion Cremer
,
Volker J. Schmid
,
Felix Kraus
,
Yolanda Markaki
,
Ines Hellmann
,
Andreas Maiser
,
Heinrich Leonhardt
,
Sam John
,
John Stamatoyannopoulos
,
Thomas Cremer
Project
DOI
Fitting large-scale structured additive regression models
Fitting regression models can be challenging when regression coefficients are high-dimensional. Especially when large spatial or …
Paul Schmidt
,
Mark Mühlau
,
Volker J. Schmid
DOI
Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development
Utilizing 3D structured illumination microscopy, we investigated the quality and quantity of nuclear invaginations and the distribution …
Jens Popken
,
Volker J. Schmid
,
Axel Strauss
,
Tuna Guengoer
,
Eckhard Wolf
,
Valeri Zakhartchenko
Project
DOI
Boosting in Nonlinear Regression Models with an Application to DCE-MRI Data
For the statistical analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, compartment models are a commonly …
Martina Feilke
,
Bernd Bischl
,
Volker J. Schmid
,
Jan Gertheiss
DOI
Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications
The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation …
Jens Popken
,
Alexander Graf
,
Stefan Krebs
,
Helmut Blum
,
Volker J. Schmid
,
Axel Strauss
,
Tuna Guengoer
,
Valeri Zakhartchenko
,
Eckhard Wolf
,
Thomas Cremer
Project
DOI
Bayesian mixed-effects model for the analysis of a series of FRAP images
The binding behavior of molecules in nuclei of living cells can be studied through the analysis of images from fluorescence recovery …
Martina Feilke
,
Katrin Schneider
,
Volker J. Schmid
DOI
Spatially regularized estimation for the analysis of dynamic contrast-enhanced magnetic resonance imaging data
Competing compartment models of different complexities have been used for the quantitative analysis of dynamic contrast-enhanced …
Julia C. Sommer
,
Jan Gertheiss
,
Volker J. Schmid
DOI
Pattern Recognition and Signal Analysis in Medical Imaging
Available as Hardcover, Paperback and eBook Description Medical imaging is one of the heaviest funded biomedical engineering research …
Anke Meyer-Baese
,
Volker J. Schmid
Trends of breast cancer incidence in Iran during 2004-2008: A bayesian space-time model
Background: Breast cancer is the most frequently diagnosed cancer in women and estimating its relative risks and trends of incidence at …
T. Jafari-Koshki
,
Volker J. Schmid
,
Behzad Mahaki
DOI
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
BACKGROUND: A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using …
Daniel Smeets
,
Yolanda Markaki
,
Volker J. Schmid
,
Felix Kraus
,
Anna Tattermusch
,
Andrea Cerase
,
Michael Sterr
,
Susanne Fiedler
,
Justin Demmerle
,
Jens Popken
,
Heinrich Leonhardt
,
Neil Brockdorff
,
Thomas Cremer
,
Lothar Schermelleh
,
Marion Cremer
Project
DOI
Spatial two-tissue compartment model for dynamic contrast-enhanced magnetic resonance imaging
In the quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging compartment models allow the uptake of contrast …
Julia C. Sommer
,
Volker J. Schmid
DOI
Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos
Jens Popken
,
Alessandro Brero
,
Daniela Koehler
,
Volker J. Schmid
,
Axel Strauss
,
Annegret Wuensch
,
Tuna Guengoer
,
Alexander Graf
,
Stefan Krebs
,
Helmut Blum
,
Valeri Zakhartchenko
,
Eckhard Wolf
,
Thomas Cremer
Project
DOI
Future Declines of Coronary Heart Disease Mortality in England and Wales Could Counter the Burden of Population Ageing
Background: Coronary Heart Disease (CHD) remains a major cause of mortality in the United Kingdom. Yet predictions of future CHD …
Maria Guzman Castillo
,
Duncan O. S. Gillespie
,
Kirk Allen
,
Piotr Bandosz
,
Volker J. Schmid
,
Simon Capewell
,
Martin O’Flaherty
Project
DOI
Sensitivity to Prior Specification in Bayesian Genome-based Prediction Models
Different statistical models have been proposed for maximizing prediction accuracy in genome-based prediction of breeding values in …
Christina Lehermeier
,
Valentin Wimmer
,
Theresa Albrecht
,
Hans-Jurgen Auinger
,
Daniel Gianola
,
Volker J. Schmid
,
Chris-Carolin Schon
DOI
Fully Bayesian Inference for Structural MRI: Application to Segmentation and Statistical Analysis of T2-Hypointensities
Aiming at iron-related T2-hypointensity, which is related to normal aging and neurodegenerative processes, we here present two …
Paul Schmidt
,
Volker J. Schmid
,
Christian Gaser
,
Dorothea Buck
,
Susanne Buhrlen
,
Annette Forschler
,
Mark Mühlau
DOI
Dissection of cell cycle dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
DNA methyltransferase 1 (Dnmt1) reestablishes methylation of hemimethylated CpG sites generated during DNA replication in mammalian …
Katrin Schneider
,
Christiane Fuchs
,
Akos Dobay
,
Andrea Rottach
,
Weihua Qin
,
Patricia Wolf
,
Jose M Alvarez-Castro
,
Marcus M Nalaskowski
,
Elisabeth Kremmer
,
Volker J. Schmid
,
Heinrich Leonhardt
,
Lothar Schermelleh
,
Christiane Dargatz
DOI
Automatic post-picking using MAPPOS improves particle image detection from cryo-EM micrographs
Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction are extensively used to reveal structural information …
Ramin Norousi
,
Stephan Wickles
,
Christoph Leidig
,
Thomas Becker
,
Volker J. Schmid
,
Roland Beckmann
,
Achim Tresch
DOI
The potential of 3D-FISH and super-resolution structured illumination microscopy for studies of 3D nuclear architecture: 3D structured illumination microscopy of defined chromosomal structures visualized by 3D (immuno)-FISH opens new perspectives for studies of nuclear architecture
Three-dimensional structured illumination microscopy (3D-SIM) has opened up new possibilities to study nuclear architecture at the …
Yolanda Markaki
,
Daniel Smeets
,
Susanne Fiedler
,
Volker J. Schmid
,
Lothar Schermelleh
,
Thomas Cremer
,
Marion Cremer
Project
DOI
Stepwise heterogeneity analysis of breast tumors in perfusion DCE-MRI datasets
Mojgan Mohajer
,
Volker J. Schmid
,
Nina A. Engels
,
Peter B. Noel
,
Ernst Rummeny
,
Karl-Hans Englmeier
,
Nina A. Engels
,
Peter B. Noel
,
Volker J. Schmid
,
Karl-Hans Englmeier
DOI
Effect of Aging on Lung Structure In Vivo: Assessment With Densitometric and Fractal Analysis of High-resolution Computed Tomography Data.
PURPOSE:: To test the hypothesis that there is a difference between the lung computed tomography (CT) microstructure of asymptomatic …
Susan J Sue Copley
,
Stamatia Giannarou
,
Volker J. Schmid
,
David M Hansell
,
Athol U Wells
,
Guang-Zhong Yang
DOI
An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis
In Multiple Sclerosis (MS), detection of T2-hyperintense white matter (WM) lesions on magnetic resonance imaging (MRI) has become a …
Paul Schmidt
,
Christian Gaser
,
Milan Arsic
,
Dorothea Buck
,
Annette Forschler
,
Achim Berthele
,
Muna Hoshi
,
Rudiger Ilg
,
Volker J. Schmid
,
Claus Zimmer
,
Bernhard Hemmer
,
Mark Muhlau
DOI
Working with the DICOM and NIfTI Data Standards in R
Two packages, oro.dicom and oro.nifti, are provided for the interaction with and manipulation of medical imaging data that conform to …
Brandon J Whitcher
,
Volker J. Schmid
,
Andrew Thornton
DOI
Voxel-based adaptive spatio-temporal modelling of perfusion cardiovascular MRI.
Contrast enhanced myocardial perfusion magnetic resonance imaging (MRI) is a promising technique, providing insight into how reduced …
Volker J. Schmid
DOI
Quantitative Analysis of Dynamic Contrast-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging for Oncology in R
The package dcemriS4 provides a complete set of data analysis tools for quantitative assessment of dynamic contrast-enhanced magnetic …
Brandon J Whitcher
,
Volker J. Schmid
DOI
Multivariate Disease Mapping of Seven Prevalent Cancers in Iran using a Shared Component Model.
Background: The aim of this study was to model the geographical variation in incidence and risk factors of seven prevalent cancers in …
Behzad Mahaki
,
Yadollah Mehrabi
,
Amir Kavousi
,
Mohammad E Akbari
,
Thomas Waldhoer
,
Volker J. Schmid
,
Mehdi Yaseri
PDF
Image analysis and statistical inference in neuroimaging with R
R is a language and environment for statistical computing and graphics. It can be considered an alternative implementation of the S …
Karsten Tabelow
,
J. D. Clayden
,
P. Lafaye de Micheaux
,
Jörg Polzehl
,
Volker J. Schmid
,
Brandon J Whitcher
DOI
How heterogeneous is the liver? A cluster analysis of DCE-MRI time series
Mojgan Mohajer
,
Volker J. Schmid
Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4.
Epigenetic alterations induced by ionizing radiation may contribute to radiation carcinogenesis. To detect relative accumulations or …
Doris M Seiler
,
Jacques Rouquette
,
Volker J. Schmid
,
Hilmar Strickfaden
,
Christian Ottmann
,
Guido a Drexler
,
Belinda Mazurek
,
Christoph Greubel
,
Volker Hable
,
Gunther Dollinger
,
Thomas Cremer
,
Anna a Friedl
DOI
Bayesian space-time analysis of Echinococcus multilocularis-infections in foxes.
A total of 26,220 foxes that were hunted or found dead in Thuringia, Germany, between 1990 and 2009 were examined for infection with …
Christoph Staubach
,
Lothar Hoffmann
,
Volker J. Schmid
,
Mario Ziller
,
Kirsten Tackmann
,
Franz J. Conraths
DOI
A comparison of Gap statistic definitions with and without logarithm function
Mojgan Mohajer
,
Karl-hans Englmeier
,
Volker J. Schmid
DOI
A Bayesian hierarchical model for DCE-MRI to evaluate treatment response in a phase II study in advanced squamous cell carcinoma of the head and neck
OBJECT: Pharmacokinetic parameters from dynamic contrast-enhanced MRI (DCE-MRI) were used to assess the perfusion effects due to …
Brandon J Whitcher
,
Volker J. Schmid
,
David J. Collins
,
Matthew R. Orton
,
Dow Mu Koh
,
Isabela Diaz De Corcuera
,
Marta Parera
,
Josep M. Del Campo
,
Nandita M. Desouza
,
Martin O. Leach
,
Kevin Harrington
,
Iman A. El-Hariry
DOI
Two Tissue Compartment Model in DCE-MRI: A Bayesian Approach
In this paper, we propose a compartment model with two interstitial space compartments for the quantitative description of the contrast …
Julia C. Karcher
,
Volker J. Schmid
DOI
Spatio-Temporal Modelling of First-Pass Perfusion Cardiovascular MRI
Myocardial perfusion MRI provides valuable insight into how coronary artery and microvascular diseases affect myocardial tissue. …
Volker J. Schmid
,
Guang-Zhong Yang
DOI
Attenuation Resilient AIF Estimation Based on Hierarchical Bayesian Modelling for First Pass Myocardial Perfusion MRI
Non-linear attenuation of the Arterial Input Function (AIF) is a major problem in first-pass MR perfusion imaging due to the high …
Volker J. Schmid
,
Peter D Gatehouse
,
Guang-Zhong Yang
DOI
Semi-parametric analysis of dynamic contrast-enhanced MRI using Bayesian P-splines
Current approaches to quantitative analysis of DCE-MRI with non-linear models involve the convolution of an arterial input function …
Volker J. Schmid
,
Brandon J Whitcher
,
Guang-Zhong Yang
PDF
DOI
Chronic obstructive pulmonary disease: current burden and future projections
AD Lopez
,
K. Shibuya
,
C. Rao
,
CD Mathers
,
Anna L. Hansell
,
Leonhard Held
,
Volker J. Schmid
,
S. Buist
Project
DOI
A two-component model for counts of infectious diseases.
We propose a stochastic model for the analysis of time series of disease counts as collected in typical surveillance systems on …
Leonhard Held
,
Mathias Hofmann
,
Michael Hohle
,
Volker J. Schmid
DOI
Statistical analysis of pharmacokinetic models in dynamic contrast-enhanced magnetic resonance imaging.
This paper assesses the estimation of kinetic parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). …
Volker J. Schmid
,
Brandon J Whitcher
,
Guang-Zhong Yang
,
N Jane Taylor
,
Anwar R. Padhani
DOI
Bayesianische Raum-Zeit-Modellierung in der Epidemiologie
This thesis is concerned with the analysis of spatial and temporal structures of epidemiological data using modern Bayes techniques. …
Volker J. Schmid
PDF
Bayesian Extrapolation of Space–Time Trends in Cancer Registry Data
We apply a full Bayesian model framework to a dataset on stomach cancer mortality in West Germany. The data are stratified by age …
Volker J. Schmid
,
Leonhard Held
Project
DOI
COPD mortality trends 1950-1999 in England & Wales - Did the 1956 Clean Air Act make a detectable difference?
Anna L. Hansell
,
Leonhard Knorr-Held
,
Nicky G Best
,
Volker J. Schmid
,
P Aylin
Project
DOI
A Bayesian model for spatial wildlife disease prevalence data
The analysis of the geographical distribution of disease on the scale of geographic areas such as administrative boundaries plays an …
Christoph Staubach
,
Volker J. Schmid
,
Leonhard Knorr-Held
,
Mario Ziller
DOI
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