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Bayesian space-time analysis of Echinococcus multilocularis-infections in foxes.

A total of 26,220 foxes that were hunted or found dead in Thuringia, Germany, between 1990 and 2009 were examined for infection with Echinococcus multilocularis, the causative agent of human alveolar echinococcosis, and 6853 animals were found …

Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4.

Epigenetic alterations induced by ionizing radiation may contribute to radiation carcinogenesis. To detect relative accumulations or losses of constitutive post-translational histone modifications in chromatin regions surrounding DNA double-strand …

How heterogeneous is the liver? A cluster analysis of DCE-MRI time series

Image analysis and statistical inference in neuroimaging with R

R is a language and environment for statistical computing and graphics. It can be considered an alternative implementation of the S language developed in the 1970s and 1980s for data analysis and graphics (Becker and Chambers, 1984; Becker et al., …

Multivariate Disease Mapping of Seven Prevalent Cancers in Iran using a Shared Component Model.

Background: The aim of this study was to model the geographical variation in incidence and risk factors of seven prevalent cancers in Iran. Methods: The data for cancers of esophagus, stomach, bladder, colorectal, lung, prostate, and female breast …

Quantitative Analysis of Dynamic Contrast-Enhanced and Diffusion-Weighted Magnetic Resonance Imaging for Oncology in R

The package dcemriS4 provides a complete set of data analysis tools for quantitative assessment of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Image processing is provided for the ANALYZE and NIfTI data formats as input with all …

Voxel-based adaptive spatio-temporal modelling of perfusion cardiovascular MRI.

Contrast enhanced myocardial perfusion magnetic resonance imaging (MRI) is a promising technique, providing insight into how reduced coronary flow affects the myocardial tissue. Stenosis in a coronary vessel leads to reduced myocardial blood flow, …

Working with the DICOM and NIfTI Data Standards in R

Two packages, oro.dicom and oro.nifti, are provided for the interaction with and manipulation of medical imaging data that conform to the DICOM standard or ANALYZE/ NIfTI formats. DICOM data, from a single file or directory tree, may be uploaded into …

Spatio-Temporal Modelling of First-Pass Perfusion Cardiovascular MRI

Myocardial perfusion MRI provides valuable insight into how coronary artery and microvascular diseases affect myocardial tissue. Stenosis in a coronary vessel leads to reduced maximum blood flow (MBF), but collaterals may secure the blood supply of …

A two-component model for counts of infectious diseases.

We propose a stochastic model for the analysis of time series of disease counts as collected in typical surveillance systems on notifiable infectious diseases. The model is based on a Poisson or negative binomial observation model with two …