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Inzidenz, Therapie und Letalitat abdominaler Aortenaneurysmen

Maximum Entropy Approach in Dynamic Contrast-Enhanced Magnetic Resonance Imaging

Quantitative analyses of the 3D nuclear landscape recorded with super-resolved fluorescence microscopy

Recent advancements of super-resolved fluorescence microscopy have revolutionized microscopic studies of cells, including the exceedingly complex structural organization of cell nuclei in space and time. In this paper we describe and discuss tools …

Boosting in Nonlinear Regression Models with an Application to DCE-MRI Data

For the statistical analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data, compartment models are a commonly used tool. By these models, the observed uptake of contrast agent in some tissue over time is linked to physiologic …

Stage-dependent remodeling of the nuclear envelope and lamina during rabbit early embryonic development

Utilizing 3D structured illumination microscopy, we investigated the quality and quantity of nuclear invaginations and the distribution of nuclear pores during rabbit early embryonic development and identified the exact time point of nucleoporin 153 …

Bayesian mixed-effects model for the analysis of a series of FRAP images

The binding behavior of molecules in nuclei of living cells can be studied through the analysis of images from fluorescence recovery after photobleaching experiments. However, there is still a lack of methodology for the statistical evaluation of …

Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications

The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform …

Spatially regularized estimation for the analysis of dynamic contrast-enhanced magnetic resonance imaging data

Competing compartment models of different complexities have been used for the quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging data. We present a spatial elastic net approach that allows to estimate the number of …

Future Declines of Coronary Heart Disease Mortality in England and Wales Could Counter the Burden of Population Ageing

Background: Coronary Heart Disease (CHD) remains a major cause of mortality in the United Kingdom. Yet predictions of future CHD mortality are potentially problematic due to population ageing and increase in obesity and diabetes. Here we explore …

Reprogramming of fibroblast nuclei in cloned bovine embryos involves major structural remodeling with both striking similarities and differences to nuclear phenotypes of in vitro fertilized embryos