More-compartment models for DCE-MRI

Standard compartment models for the analysis of Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) are based on one or two compartments, parts of the tissue, which exchange the contrast agent. However, these models are often to simplistic, especially when analysing DCE-MR images of cancerous tissue. On the other hand, models with more than two compartments suffer from redundancy issues, that is, the model parameters cannot be identified. Julia Sommer has worked on ways to make more-compartment-models identifiable by using spatial regularization methods. In two recent publications, she also shows how the number of compartments can be found.

Spatial two-tissue compartment model for dynamic contrast-enhanced magnetic resonance imaging

In the quantitative analysis of dynamic contrast-enhanced magnetic resonance imaging compartment models allow the uptake of contrast medium to be described with biologically meaningful kinetic parameters. As simple models often fail to describe …