Heinrich Leonhardt

Latest

• Cohesin depleted cells pass through mitosis and reconstitute a functional nuclear architecture.
• Initial high-resolution microscopic mapping of active and inactive regulatory sequences proves non-random 3D arrangements in chromatin domain clusters
• Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.
• Dissection of cell cycle dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling